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Human Monoclonal IgM Antibody Promotes CNS Myelin Repair Independent of Fc Function

The human monoclonal IgM antibody sHIgM22 and mouse IgM monoclonal antibody 94.03 bind to oligodendrocytes, induce calcium signals in cultured glial cells, and promote remyelination in mouse models of multiple sclerosis. In order to address the mechanisms employed by these antibodies to promote CNS...

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Détails bibliographiques
Publié dans:Brain Pathol
Auteurs principaux: Ciric, Bogoljub, Howe, Charles L., Soldan, Mateo Paz, Warrington, Arthur E., Bieber, Allan J., Van Keulen, Virginia, Rodriguez, Moses, Pease, Larry R.
Format: Artigo
Langue:Inglês
Publié: Blackwell Publishing Ltd 2006
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096021/
https://ncbi.nlm.nih.gov/pubmed/14655764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2003.tb00489.x
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