A Human IgM Signals Axon Outgrowth: Coupling Lipid Raft to Microtubules

Mouse and human IgMs support neurite extension from primary cerebellar granule neurons. In this study using primary hippocampal and cortical neurons we demonstrate that a recombinant human IgM, rHIgM12, promotes axon outgrowth by coupling membrane domains (lipid rafts) to microtubules. rHIgM12 binds...

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Détails bibliographiques
Auteurs principaux: Xu, Xiaohua, Warrington, Arthur E., Wright, Brent R., Bieber, Allan J., Van Keulen, Virginia, Pease, Larry R., Rodriguez, Moses
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3171625/
https://ncbi.nlm.nih.gov/pubmed/21824142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07416.x
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