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Therapeutics to Promote CNS Repair: A Natural Human Neuron-Binding IgM Regulates Membrane-Raft Dynamics and Improves Motility in a Mouse Model of Multiple Sclerosis

We have discovered a role for natural autoantibodies in central nervous system repair, remyelination and axon protection. These natural human antibodies are of the immunoglobulin M (IgM) isotype, and they bind to the surface of neural cells. The epitope of the antibody includes sialic acid because t...

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Библиографические подробности
Главные авторы: Xu, Xiaohua, Denic, Aleksandar, Warrington, Arthur E., Bieber, Allan J., Rodriguez, Moses
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548056/
https://ncbi.nlm.nih.gov/pubmed/22990667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10875-012-9795-8
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