Intraneuronal APP/Aβ Trafficking and Plaque Formation in β‐Amyloid Precursor Protein and Presenilin‐1 Transgenic Mice

Neuropil deposition of β‐amyloid peptides Aβ40 and Aβ42 is believed to be the key event in the neurodegenerative processes of Alzheimer's disease (AD). Since Aβ seems to carry a transport signal that is required for axonal sorting of its precursor β‐amyloid precursor protein (APP), we studied t...

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Detalles Bibliográficos
Publicado en:Brain Pathol
Main Authors: Wirths, Oliver, Multhaup, Gerd, Czech, Christian, Feldmann, Nicole, Blanchard, Véronique, Tremp, Günter, Beyreuther, Konrad, Pradier, Laurent, Bayer, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 2006
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095864/
https://ncbi.nlm.nih.gov/pubmed/12146796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2002.tb00442.x
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