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Cell-type-specific processing of the amyloid precursor protein by Presenilin during Drosophila development

The cleavage of proteins within their transmembrane domain by Presenilin (PS) has an important role in different signalling pathways and in Alzheimer's disease. Nevertheless, not much is known about the regulation of PS activity. It has been suggested that substrate recognition by the PS comple...

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Bibliographic Details
Main Authors: Loewer, Alexander, Soba, Peter, Beyreuther, Konrad, Paro, Renato, Merdes, Gunter
Format: Artigo
Language:Inglês
Published: 2004
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1299033/
https://ncbi.nlm.nih.gov/pubmed/15105831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400122
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