Tetrahydrophthalazinone Inhibitor of Phosphodiesterase with In Vitro Activity against Intracellular Trypanosomatids

The phosphodiesterase inhibitor tetrahydrophthalazinone NPD-008 was explored by phenotypic in vitro screening, target validation, and ultrastructural approaches against Trypanosoma cruzi. NPD-008 displayed activity against different forms and strains of T. cruzi (50% effective concentration [EC(50)]...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: de Araújo, Julianna Siciliano, Peres, Raiza Brandão, Bernardino da Silva, Patrícia, Batista, Marcos Meuser, Sterk, Geert Jan, Maes, Louis, Caljon, Guy, Leurs, Rob, de Koning, Harry P., Kalejaiye, Titilola D., Soeiro, Maria de Nazaré Correia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2021
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092546/
https://ncbi.nlm.nih.gov/pubmed/33361300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00960-20
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