Tetrahydrophthalazinone Inhibitor of Phosphodiesterase with In Vitro Activity against Intracellular Trypanosomatids

The phosphodiesterase inhibitor tetrahydrophthalazinone NPD-008 was explored by phenotypic in vitro screening, target validation, and ultrastructural approaches against Trypanosoma cruzi. NPD-008 displayed activity against different forms and strains of T. cruzi (50% effective concentration [EC(50)]...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: de Araújo, Julianna Siciliano, Peres, Raiza Brandão, Bernardino da Silva, Patrícia, Batista, Marcos Meuser, Sterk, Geert Jan, Maes, Louis, Caljon, Guy, Leurs, Rob, de Koning, Harry P., Kalejaiye, Titilola D., Soeiro, Maria de Nazaré Correia
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2021
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092546/
https://ncbi.nlm.nih.gov/pubmed/33361300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00960-20
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