Tetrahydrophthalazinone Inhibitor of Phosphodiesterase with In Vitro Activity against Intracellular Trypanosomatids

The phosphodiesterase inhibitor tetrahydrophthalazinone NPD-008 was explored by phenotypic in vitro screening, target validation, and ultrastructural approaches against Trypanosoma cruzi. NPD-008 displayed activity against different forms and strains of T. cruzi (50% effective concentration [EC(50)]...

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Dettagli Bibliografici
Pubblicato in:Antimicrob Agents Chemother
Autori principali: de Araújo, Julianna Siciliano, Peres, Raiza Brandão, Bernardino da Silva, Patrícia, Batista, Marcos Meuser, Sterk, Geert Jan, Maes, Louis, Caljon, Guy, Leurs, Rob, de Koning, Harry P., Kalejaiye, Titilola D., Soeiro, Maria de Nazaré Correia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2021
Soggetti:
Experimental Therapeutics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092546/
https://ncbi.nlm.nih.gov/pubmed/33361300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00960-20
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