Tetrahydrophthalazinone Inhibitor of Phosphodiesterase with In Vitro Activity against Intracellular Trypanosomatids

The phosphodiesterase inhibitor tetrahydrophthalazinone NPD-008 was explored by phenotypic in vitro screening, target validation, and ultrastructural approaches against Trypanosoma cruzi. NPD-008 displayed activity against different forms and strains of T. cruzi (50% effective concentration [EC(50)]...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Antimicrob Agents Chemother
Autors principals: de Araújo, Julianna Siciliano, Peres, Raiza Brandão, Bernardino da Silva, Patrícia, Batista, Marcos Meuser, Sterk, Geert Jan, Maes, Louis, Caljon, Guy, Leurs, Rob, de Koning, Harry P., Kalejaiye, Titilola D., Soeiro, Maria de Nazaré Correia
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2021
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092546/
https://ncbi.nlm.nih.gov/pubmed/33361300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00960-20
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars