Tetrahydrophthalazinone Inhibitor of Phosphodiesterase with In Vitro Activity against Intracellular Trypanosomatids

The phosphodiesterase inhibitor tetrahydrophthalazinone NPD-008 was explored by phenotypic in vitro screening, target validation, and ultrastructural approaches against Trypanosoma cruzi. NPD-008 displayed activity against different forms and strains of T. cruzi (50% effective concentration [EC(50)]...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: de Araújo, Julianna Siciliano, Peres, Raiza Brandão, Bernardino da Silva, Patrícia, Batista, Marcos Meuser, Sterk, Geert Jan, Maes, Louis, Caljon, Guy, Leurs, Rob, de Koning, Harry P., Kalejaiye, Titilola D., Soeiro, Maria de Nazaré Correia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2021
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092546/
https://ncbi.nlm.nih.gov/pubmed/33361300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00960-20
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