Discovery of Diaryl Ether Substituted Tetrahydrophthalazinones as TbrPDEB1 Inhibitors Following Structure-Based Virtual Screening

Several members of the 3′,5′-cyclic nucleotide phosphodiesterase (PDE) family play an essential role in cellular processes, which has labeled them as interesting targets for various diseases. The parasitic protozoan Trypanosoma brucei, causative agent of human African trypanosomiasis, contains sever...

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Bibliografski detalji
Izdano u:Front Chem
Glavni autori: de Heuvel, Erik, Kooistra, Albert J., Edink, Ewald, van Klaveren, Sjors, Stuijt, Jeffrey, van der Meer, Tiffany, Sadek, Payman, Mabille, Dorien, Caljon, Guy, Maes, Louis, Siderius, Marco, de Esch, Iwan J. P., Sterk, Geert Jan, Leurs, Rob
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2021
Teme:
Chemistry
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7859335/
https://ncbi.nlm.nih.gov/pubmed/33553105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.608030
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