Efficacy of Novel Pyrazolone Phosphodiesterase Inhibitors in Experimental Mouse Models of Trypanosoma cruzi

Pyrazolones are heterocyclic compounds with interesting biological properties. Some derivatives inhibit phosphodiesterases (PDEs) and thereby increase the cellular concentration of cyclic AMP (cAMP), which plays a vital role in the control of metabolism in eukaryotic cells, including the protozoan T...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: de Araújo, Julianna Siciliano, França da Silva, Cristiane, Batista, Denise da Gama Jaén, Nefertiti, Aline, Fiuza, Ludmila Ferreira de Almeida, Fonseca-Berzal, Cristina Rosa, Bernardino da Silva, Patrícia, Batista, Marcos Meuser, Sijm, Maarten, Kalejaiye, Titilola D., de Koning, Harry P., Maes, Louis, Sterk, Geert Jan, Leurs, Rob, Soeiro, Maria de Nazaré Correia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449165/
https://ncbi.nlm.nih.gov/pubmed/32601163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00414-20
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