Efficacy of Novel Pyrazolone Phosphodiesterase Inhibitors in Experimental Mouse Models of Trypanosoma cruzi

Pyrazolones are heterocyclic compounds with interesting biological properties. Some derivatives inhibit phosphodiesterases (PDEs) and thereby increase the cellular concentration of cyclic AMP (cAMP), which plays a vital role in the control of metabolism in eukaryotic cells, including the protozoan T...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: de Araújo, Julianna Siciliano, França da Silva, Cristiane, Batista, Denise da Gama Jaén, Nefertiti, Aline, Fiuza, Ludmila Ferreira de Almeida, Fonseca-Berzal, Cristina Rosa, Bernardino da Silva, Patrícia, Batista, Marcos Meuser, Sijm, Maarten, Kalejaiye, Titilola D., de Koning, Harry P., Maes, Louis, Sterk, Geert Jan, Leurs, Rob, Soeiro, Maria de Nazaré Correia
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7449165/
https://ncbi.nlm.nih.gov/pubmed/32601163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00414-20
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