Molecular insights into substrate recognition and discrimination by the N-terminal domain of Lon AAA+ protease

The Lon AAA+ protease (LonA) is a ubiquitous ATP-dependent proteolytic machine, which selectively degrades damaged proteins or native proteins carrying exposed motifs (degrons). Here we characterize the structural basis for substrate recognition and discrimination by the N-terminal domain (NTD) of L...

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Vydáno v:eLife
Hlavní autoři: Tzeng, Shiou-Ru, Tseng, Yin-Chu, Lin, Chien-Chu, Hsu, Chia-Ying, Huang, Shing-Jong, Kuo, Yi-Ting, Chang, Chung-I
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2021
Témata:
Biochemistry and Chemical Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8087443/
https://ncbi.nlm.nih.gov/pubmed/33929321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.64056
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