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N domain of the Lon AAA+ protease controls assembly and substrate choice

Abstract: The protein quality control network (pQC) plays critical roles in maintaining protein and cellular homeostasis, especially during stress. Lon is a major pQC AAA+ protease, conserved from bacteria to human mitochondria. It is the principal enzyme that degrades most unfolded or damaged prote...

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Vydáno v:Protein Sci
Hlavní autoři: Brown, Breann L., Vieux, Ellen F., Kalastavadi, Tejas, Kim, SaRa, Chen, James Z., Baker, Tania A.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6566560/
https://ncbi.nlm.nih.gov/pubmed/30461098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3553
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