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Roles of the N domain of the AAA+ Lon protease in substrate recognition, allosteric regulation, and chaperone activity

Degron binding regulates the activities of the AAA+ Lon protease in addition to targeting proteins for degradation. The sul20 degron from the cell-division inhibitor SulA is shown here to bind to the N domain of E. coli Lon, and the recognition site is identified by crosslinking and scanning for mut...

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Main Authors: Wohlever, Matthew L., Baker, Tania A., Sauer, Robert T.
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3877180/
https://ncbi.nlm.nih.gov/pubmed/24205897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12444
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