Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ

Cancer is characterized by pervasive epigenetic alterations with enhancer dysfunction orchestrating the aberrant cancer transcriptional programs and transcriptional dependencies. Here, we epigenetically characterize human colorectal cancer (CRC) using de novo chromatin state discovery on a library o...

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Published in:Nat Commun
Main Authors: Della Chiara, Giulia, Gervasoni, Federica, Fakiola, Michaela, Godano, Chiara, D’Oria, Claudia, Azzolin, Luca, Bonnal, Raoul Jean Pierre, Moreni, Giulia, Drufuca, Lorenzo, Rossetti, Grazisa, Ranzani, Valeria, Bason, Ramona, De Simone, Marco, Panariello, Francesco, Ferrari, Ivan, Fabbris, Tanya, Zanconato, Francesca, Forcato, Mattia, Romano, Oriana, Caroli, Jimmy, Gruarin, Paola, Sarnicola, Maria Lucia, Cordenonsi, Michelangelo, Bardelli, Alberto, Zucchini, Nicola, Ceretti, Andrea Pisani, Mariani, Nicolò Maria, Cassingena, Andrea, Sartore-Bianchi, Andrea, Testa, Giuseppe, Gianotti, Luca, Opocher, Enrico, Pisati, Federica, Tripodo, Claudio, Macino, Giuseppe, Siena, Salvatore, Bicciato, Silvio, Piccolo, Stefano, Pagani, Massimiliano
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2021
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8058065/
https://ncbi.nlm.nih.gov/pubmed/33879786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22544-y
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