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TREX1 as a Novel Immunotherapeutic Target
Mutations in the TREX1 3’ → 5’ exonuclease are associated with a spectrum of autoimmune disease phenotypes in humans and mice. Failure to degrade DNA activates the cGAS-STING DNA-sensing pathway signaling a type-I interferon (IFN) response that ultimately drives immune system activation. TREX1 and t...
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| 出版年: | Front Immunol |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Frontiers Media S.A.
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8047136/ https://ncbi.nlm.nih.gov/pubmed/33868310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.660184 |
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