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TREX1 – Apex predator of cytosolic DNA metabolism
The cytosolic Three prime Repair EXonuclease 1 (TREX1) is a powerful DNA-degrading enzyme required for clearing cytosolic DNA to prevent aberrant inflammation and autoimmunity. In the absence of TREX1 activity, cytosolic DNA pattern recognition receptors of the innate immune system are constitutivel...
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| Publicado no: | DNA Repair (Amst) |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7985832/ https://ncbi.nlm.nih.gov/pubmed/32615442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2020.102894 |
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