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TREX1 – Apex predator of cytosolic DNA metabolism
The cytosolic Three prime Repair EXonuclease 1 (TREX1) is a powerful DNA-degrading enzyme required for clearing cytosolic DNA to prevent aberrant inflammation and autoimmunity. In the absence of TREX1 activity, cytosolic DNA pattern recognition receptors of the innate immune system are constitutivel...
Shranjeno v:
| izdano v: | DNA Repair (Amst) |
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| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7985832/ https://ncbi.nlm.nih.gov/pubmed/32615442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2020.102894 |
| Oznake: |
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