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Measuring TREX1 and TREX2 exonuclease activities
Three-prime Repair Exonuclease (TREX1) degrades ssDNA and dsDNA. TREX1 localizes to the perinuclear space in cells and degrades cytosolic DNA to prevent aberrant nucleic acid sensing and immune activation in humans and mice. Mutations in the TREX1 gene cause a spectrum of human autoimmune diseases i...
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| Published in: | Methods Enzymol |
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| Main Authors: | , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6893858/ https://ncbi.nlm.nih.gov/pubmed/31455522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/bs.mie.2019.05.004 |
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