A carregar...
TREX1 as a Novel Immunotherapeutic Target
Mutations in the TREX1 3’ → 5’ exonuclease are associated with a spectrum of autoimmune disease phenotypes in humans and mice. Failure to degrade DNA activates the cGAS-STING DNA-sensing pathway signaling a type-I interferon (IFN) response that ultimately drives immune system activation. TREX1 and t...
Na minha lista:
| Publicado no: | Front Immunol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2021
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8047136/ https://ncbi.nlm.nih.gov/pubmed/33868310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.660184 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|