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Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease
The TREX1 gene encodes a potent DNA exonuclease, and mutations in TREX1 cause a spectrum of lupus-like autoimmune diseases. Most lupus patients develop autoantibodies to double-stranded DNA (dsDNA), but the source of DNA antigen is unknown. The TREX1 D18N mutation causes a monogenic, cutaneous form...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4413332/ https://ncbi.nlm.nih.gov/pubmed/25848017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423804112 |
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