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Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease
The TREX1 gene encodes a potent DNA exonuclease, and mutations in TREX1 cause a spectrum of lupus-like autoimmune diseases. Most lupus patients develop autoantibodies to double-stranded DNA (dsDNA), but the source of DNA antigen is unknown. The TREX1 D18N mutation causes a monogenic, cutaneous form...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4413332/ https://ncbi.nlm.nih.gov/pubmed/25848017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423804112 |
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