The TREX1 Double-stranded DNA Degradation Activity Is Defective in Dominant Mutations Associated with Autoimmune Disease

Mutations in TREX1 have been linked to a spectrum of human autoimmune diseases including Aicardi-Goutières syndrome (AGS), familial chilblain lupus (FCL), systemic lupus erythematosus, and retinal vasculopathy and cerebral leukodystrophy. A common feature in these conditions is the frequent detectio...

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Detalhes bibliográficos
Main Authors: Lehtinen, Duane A., Harvey, Scott, Mulcahy, Matthew J., Hollis, Thomas, Perrino, Fred W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2581595/
https://ncbi.nlm.nih.gov/pubmed/18805785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806155200
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