Aberrant DNA Polymerase α Is Excluded from the Nucleus by Defective Import and Degradation in the Nucleus

DNA polymerase α is essential for the onset of eukaryotic DNA replication. Its correct folding and assembly within the nuclear replication pre-initiation complex is crucial for normal cell cycle progression and genome maintenance. Due to a single point mutation in the largest DNA polymerase α subuni...

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Main Authors: Eichinger, Christian S., Mizuno, Takeshi, Mizuno, Keiko, Miyake, Yasuyuki, Yanagi, Ken-ichiro, Imamoto, Naoko, Hanaoka, Fumio
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
DNA: Replication, Repair, Recombination, and Chromosome Dynamics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781615/
https://ncbi.nlm.nih.gov/pubmed/19726690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024760
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