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TREX1 D18N mice fail to process erythroblast DNA resulting in inflammation and dysfunctional erythropoiesis
Anaemia is commonly observed in chronic inflammatory conditions, including systemic lupus erythematosus (SLE), where ~50% of patients display clinical signs of anaemia. Mutation at the aspartate residue 18 of the three prime repair exonuclease 1 (TREX1) gene causes a monogenic form of cutaneous lupu...
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| Veröffentlicht in: | Autoimmunity |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6513733/ https://ncbi.nlm.nih.gov/pubmed/30422000 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/08916934.2018.1522305 |
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