TREX1 as a Novel Immunotherapeutic Target

Mutations in the TREX1 3’ → 5’ exonuclease are associated with a spectrum of autoimmune disease phenotypes in humans and mice. Failure to degrade DNA activates the cGAS-STING DNA-sensing pathway signaling a type-I interferon (IFN) response that ultimately drives immune system activation. TREX1 and t...

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Publicat a:Front Immunol
Autors principals: Hemphill, Wayne O., Simpson, Sean R., Liu, Mingyong, Salsbury, Freddie R., Hollis, Thomas, Grayson, Jason M., Perrino, Fred W.
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8047136/
https://ncbi.nlm.nih.gov/pubmed/33868310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.660184
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