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TREX1 – Apex predator of cytosolic DNA metabolism
The cytosolic Three prime Repair EXonuclease 1 (TREX1) is a powerful DNA-degrading enzyme required for clearing cytosolic DNA to prevent aberrant inflammation and autoimmunity. In the absence of TREX1 activity, cytosolic DNA pattern recognition receptors of the innate immune system are constitutivel...
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| Pubblicato in: | DNA Repair (Amst) |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7985832/ https://ncbi.nlm.nih.gov/pubmed/32615442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2020.102894 |
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