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Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases

[Image: see text] Protein tyrosine phosphatases (PTPs) play an important role in cellular signaling and have been implicated in human cancers, diabetes, and obesity. Despite shared catalytic mechanisms and transition states for the chemical steps of catalysis, catalytic rates within the PTP family v...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Crean, Rory M., Biler, Michal, van der Kamp, Marc W., Hengge, Alvan C., Kamerlin, Shina C. L.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2021
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8031367/
https://ncbi.nlm.nih.gov/pubmed/33661624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c11806
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