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The Molecular Details of WPD-Loop Movement Differ in the Protein-Tyrosine Phosphatases YopH and PTP1B
The movement of a conserved protein loop (the WPD-loop) is important in catalysis by protein tyrosine phosphatases (PTPs). Using kinetics, isotope effects, and X-ray crystallography, the different effects arising from mutation of the conserved tryptophan in the WPD-loop were compared in two PTPs, th...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3422214/ https://ncbi.nlm.nih.gov/pubmed/22698963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2012.06.002 |
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