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The Molecular Details of WPD-Loop Movement Differ in the Protein-Tyrosine Phosphatases YopH and PTP1B

The movement of a conserved protein loop (the WPD-loop) is important in catalysis by protein tyrosine phosphatases (PTPs). Using kinetics, isotope effects, and X-ray crystallography, the different effects arising from mutation of the conserved tryptophan in the WPD-loop were compared in two PTPs, th...

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Detalhes bibliográficos
Main Authors: Brandão, Tiago A. S., Johnson, Sean J., Hengge, Alvan C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422214/
https://ncbi.nlm.nih.gov/pubmed/22698963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2012.06.002
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