Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites

[Image: see text] Catalysis in protein tyrosine phosphatases (PTPs) involves movement of a protein loop called the WPD loop that brings a conserved aspartic acid into the active site to function as a general acid. Mutation of the tryptophan in the WPD loop of the PTP YopH to any other residue with a...

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Publicado en:Biochemistry
Autores principales: Moise, Gwendolyn, Gallup, Nathan M., Alexandrova, Anastassia N., Hengge, Alvan C., Johnson, Sean J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4887194/
https://ncbi.nlm.nih.gov/pubmed/26445170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00496
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