Biomolecular interactions of small-molecule inhibitors affecting the YopH protein tyrosine phosphatase

We have developed competitive and direct binding methods to examine small-molecule inhibitors of protein tyrosine phosphatase (PTPase) activity. Focusing on the Yersinia outer protein H (YopH), a potent bacterial PTPase, we describe how an understanding of the kinetic interactions involving YopH, pe...

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Huvudupphovsmän: Hogan, Megan, Bahta, Medhanit, Cherry, Scott, Lountos, George T., Tropea, Joseph E., Zhao, Bryan M., Burke, Terrence R., Waugh, David S., Ulrich, Robert G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3573263/
https://ncbi.nlm.nih.gov/pubmed/23241354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cbdd.12097
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