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A Rapid Oxime Linker-Based Library Approach to Identification of Bivalent Inhibitors of the Yersinia pestis Protein-Tyrosine Phosphatase, YopH
A bivalent tethered approach toward YopH inhibitor development is presented that joins aldehydes with mixtures of bis-aminooxy-containing linkers using oxime coupling. The methodology is characterized by its facility and ease of use and its ability to rapidly identify low micromolar affinity inhibit...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2863121/ https://ncbi.nlm.nih.gov/pubmed/20350805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.03.058 |
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