A Rapid Oxime Linker-Based Library Approach to Identification of Bivalent Inhibitors of the Yersinia pestis Protein-Tyrosine Phosphatase, YopH

A bivalent tethered approach toward YopH inhibitor development is presented that joins aldehydes with mixtures of bis-aminooxy-containing linkers using oxime coupling. The methodology is characterized by its facility and ease of use and its ability to rapidly identify low micromolar affinity inhibit...

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Détails bibliographiques
Auteurs principaux: Liu, Fa, Hakami, Ramin Mollaaghababa, Dyas, Beverly, Bahta, Medhanit, Lountos, George T., Waugh, David S., Ulrich, Robert G., Burke, Terrence R.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863121/
https://ncbi.nlm.nih.gov/pubmed/20350805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.03.058
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