Targeting Protein–Protein Interactions of Tyrosine Phosphatases with Microarrayed Fragment Libraries Displayed on Phosphopeptide Substrate Scaffolds

Chemical library screening approaches that focus exclusively on catalytic events may overlook unique effects of protein–protein interactions that can be exploited for development of specific inhibitors. Phosphotyrosyl (pTyr) residues embedded in peptide motifs comprise minimal recognition elements t...

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Detalhes bibliográficos
Publicado no:ACS Comb Sci
Main Authors: Hogan, Megan, Bahta, Medhanit, Tsuji, Kohei, Nguyen, Trung X., Cherry, Scott, Lountos, George T., Tropea, Joseph E., Zhao, Bryan M., Zhao, Xue Zhi, Waugh, David S., Burke, Terrence R., Ulrich, Robert G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132114/
https://ncbi.nlm.nih.gov/pubmed/30629404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.8b00122
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