Targeting Protein–Protein Interactions of Tyrosine Phosphatases with Microarrayed Fragment Libraries Displayed on Phosphopeptide Substrate Scaffolds

Chemical library screening approaches that focus exclusively on catalytic events may overlook unique effects of protein–protein interactions that can be exploited for development of specific inhibitors. Phosphotyrosyl (pTyr) residues embedded in peptide motifs comprise minimal recognition elements t...

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Gepubliceerd in:ACS Comb Sci
Hoofdauteurs: Hogan, Megan, Bahta, Medhanit, Tsuji, Kohei, Nguyen, Trung X., Cherry, Scott, Lountos, George T., Tropea, Joseph E., Zhao, Bryan M., Zhao, Xue Zhi, Waugh, David S., Burke, Terrence R., Ulrich, Robert G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8132114/
https://ncbi.nlm.nih.gov/pubmed/30629404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.8b00122
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