Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases

[Image: see text] Catalysis by protein tyrosine phosphatases (PTPs) relies on the motion of a flexible protein loop (the WPD-loop) that carries a residue acting as a general acid/base catalyst during the PTP-catalyzed reaction. The orthogonal substitutions of a noncatalytic residue in the WPD-loops...

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Udgivet i:JACS Au
Main Authors: Shen, Ruidan, Crean, Rory M., Johnson, Sean J., Kamerlin, Shina C. L., Hengge, Alvan C.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8297725/
https://ncbi.nlm.nih.gov/pubmed/34308419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacsau.1c00054
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