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Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases
[Image: see text] Catalysis by protein tyrosine phosphatases (PTPs) relies on the motion of a flexible protein loop (the WPD-loop) that carries a residue acting as a general acid/base catalyst during the PTP-catalyzed reaction. The orthogonal substitutions of a noncatalytic residue in the WPD-loops...
Tallennettuna:
| Julkaisussa: | JACS Au |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American
Chemical Society
2021
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| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8297725/ https://ncbi.nlm.nih.gov/pubmed/34308419 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacsau.1c00054 |
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