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Kinetic Isotope Effects In The Characterization Of Catalysis by Protein Tyrosine Phosphatases

Although thermodynamically favorable, the uncatalyzed hydrolysis of phosphate monoesters is extraordinarily slow, making phosphatases among the most catalytically efficient enzymes known. Protein-tyrosine phosphatases (PTPs) are ubiquitous in biology, and kinetic isotope effects were one of the key...

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Detalles Bibliográficos
Publicado en:Biochim Biophys Acta
Autor Principal: Hengge, Alvan C.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4591087/
https://ncbi.nlm.nih.gov/pubmed/25840000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.03.010
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