Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases

[Image: see text] Protein tyrosine phosphatases (PTPs) play an important role in cellular signaling and have been implicated in human cancers, diabetes, and obesity. Despite shared catalytic mechanisms and transition states for the chemical steps of catalysis, catalytic rates within the PTP family v...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Crean, Rory M., Biler, Michal, van der Kamp, Marc W., Hengge, Alvan C., Kamerlin, Shina C. L.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2021
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8031367/
https://ncbi.nlm.nih.gov/pubmed/33661624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c11806
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