Loop Dynamics and Enzyme Catalysis in Protein Tyrosine Phosphatases

[Image: see text] Protein tyrosine phosphatases (PTPs) play an important role in cellular signaling and have been implicated in human cancers, diabetes, and obesity. Despite shared catalytic mechanisms and transition states for the chemical steps of catalysis, catalytic rates within the PTP family v...

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Bibliografiset tiedot
Julkaisussa:J Am Chem Soc
Päätekijät: Crean, Rory M., Biler, Michal, van der Kamp, Marc W., Hengge, Alvan C., Kamerlin, Shina C. L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2021
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8031367/
https://ncbi.nlm.nih.gov/pubmed/33661624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c11806
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