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Conformational motions regulate phosphoryl transfer in related protein tyrosine phosphatases

Many studies have implicated a role for conformational motions during the catalytic cycle, acting to optimize the binding pocket or facilitate product release, but a more intimate role in the chemical reaction has not been described. We address this by monitoring active-site loop motion in two prote...

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Main Authors: Whittier, Sean K., Hengge, Alvan C., Loria, J. Patrick
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4078984/
https://ncbi.nlm.nih.gov/pubmed/23970698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1241735
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