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Conformational motions regulate phosphoryl transfer in related protein tyrosine phosphatases
Many studies have implicated a role for conformational motions during the catalytic cycle, acting to optimize the binding pocket or facilitate product release, but a more intimate role in the chemical reaction has not been described. We address this by monitoring active-site loop motion in two prote...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4078984/ https://ncbi.nlm.nih.gov/pubmed/23970698 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1241735 |
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