Protein Tyrosine Phosphatase 1B Regulates Pyruvate Kinase M2 Tyrosine Phosphorylation

Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of glucose homeostasis and adiposity and is a drug target for the treatment of obesity and diabetes. Here we identify pyruvate kinase M2 (PKM2) as a novel PTP1B substrate in adipocytes. PTP1B deficiency leads to increased PKM2 tota...

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Autores principales: Bettaieb, Ahmed, Bakke, Jesse, Nagata, Naoto, Matsuo, Kosuke, Xi, Yannan, Liu, Siming, AbouBechara, Daniel, Melhem, Ramzi, Stanhope, Kimber, Cummings, Bethany, Graham, James, Bremer, Andrew, Zhang, Sheng, Lyssiotis, Costas A., Zhang, Zhong-Yin, Cantley, Lewis C., Havel, Peter J., Haj, Fawaz G.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682537/
https://ncbi.nlm.nih.gov/pubmed/23640882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.441469
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