Protein Tyrosine Phosphatase 1B Deficiency Potentiates PERK/eIF2α Signaling in Brown Adipocytes

BACKGROUND: Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of glucose homeostasis and body mass, and has been implicated in endoplasmic reticulum (ER) stress. Herein, we assess the role of PTP1B in ER stress in brown adipocytes, which are key regulators of thermogenesis and met...

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Main Authors: Bettaieb, Ahmed, Matsuo, Kosuke, Matsuo, Izumi, Wang, Shuo, Melhem, Ramzi, Koromilas, Antonis E., Haj, Fawaz G.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2012
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317973/
https://ncbi.nlm.nih.gov/pubmed/22509299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034412
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