Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice

AIMS/HYPOTHESIS: T cell protein tyrosine phosphatase (TCPTP, encoded by PTPN2) regulates cytokine-induced pancreatic beta cell apoptosis and may contribute to the pathogenesis of type 1 diabetes. However, the role of TCPTP in pancreatic endocrine function and insulin secretion remains largely unknow...

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Detalhes bibliográficos
Publicado no:Diabetologia
Main Authors: Xi, Yannan, Liu, Siming, Bettaieb, Ahmed, Matsuo, Kosuke, Matsuo, Izumi, Hosein, Ellen, Chahed, Samah, Wiede, Florian, Zhang, Sheng, Zhang, Zhong-Yin, Kulkarni, Rohit N., Tiganis, Tony, Haj, Fawaz G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258175/
https://ncbi.nlm.nih.gov/pubmed/25338551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-014-3413-7
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