Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products

[Image: see text] Natural compounds are an important class of potent drug molecules including some retrospectively found to act as stabilizers of protein–protein interactions (PPIs). However, the design of synthetic PPI stabilizers remains an understudied approach. To date, there are limited example...

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Publicado en:J Am Chem Soc
Autores principales: Wolter, Madita, de Vink, Pim, Neves, João Filipe, Srdanović, Sonja, Higuchi, Yusuke, Kato, Nobuo, Wilson, Andrew, Landrieu, Isabelle, Brunsveld, Luc, Ottmann, Christian
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2020
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022324/
https://ncbi.nlm.nih.gov/pubmed/32501683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c02151
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