Reversible Covalent Imine-Tethering for Selective Stabilization of 14-3-3 Hub Protein Interactions

[Image: see text] The stabilization of protein complexes has emerged as a promising modality, expanding the number of entry points for novel therapeutic intervention. Targeting proteins that mediate protein–protein interactions (PPIs), such as hub proteins, is equally challenging and rewarding as th...

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Argitaratua izan da:J Am Chem Soc
Egile Nagusiak: Cossar, Peter J., Wolter, Madita, van Dijck, Lars, Valenti, Dario, Levy, Laura M., Ottmann, Christian, Brunsveld, Luc
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Chemical Society 2021
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8193639/
https://ncbi.nlm.nih.gov/pubmed/34047554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c03035
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