Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers

[Image: see text] The systematic discovery of functional fragments binding to the composite interface of protein complexes is a first critical step for the development of orthosteric stabilizers of protein–protein interactions (PPIs). We have previously shown that disulfide trapping successfully yie...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Sijbesma, Eline, Hallenbeck, Kenneth K., Andrei, Sebastian A., Rust, Reanne R., Adriaans, Joris M. C., Brunsveld, Luc, Arkin, Michelle R., Ottmann, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8201753/
https://ncbi.nlm.nih.gov/pubmed/34136078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00088
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