Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening

[Image: see text] Proteins typically interact with multiple binding partners, and often different parts of their surfaces are employed to establish these protein–protein interactions (PPIs). Members of the class of 14-3-3 adapter proteins bind to several hundred other proteins in the cell. Multiple...

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Udgivet i:Biochemistry
Main Authors: Sijbesma, Eline, Skora, Lukasz, Leysen, Seppe, Brunsveld, Luc, Koch, Uwe, Nussbaumer, Peter, Jahnke, Wolfgang, Ottmann, Christian
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2017
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5543393/
https://ncbi.nlm.nih.gov/pubmed/28681606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.7b00153
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