Fragment‐Based Stabilizers of Protein–Protein Interactions through Imine‐Based Tethering

Small‐molecule stabilization of protein–protein interactions (PPIs) is a promising concept in drug discovery, however the question how to identify or design chemical starting points in a “bottom‐up” approach is largely unanswered. We report a novel concept for identifying initial chemical matter for...

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Dettagli Bibliografici
Pubblicato in:Angew Chem Int Ed Engl
Autori principali: Wolter, Madita, Valenti, Dario, Cossar, Peter J., Levy, Laura M., Hristeva, Stanimira, Genski, Thorsten, Hoffmann, Torsten, Brunsveld, Luc, Tzalis, Dimitrios, Ottmann, Christian
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
Soggetti:
Communications
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7756862/
https://ncbi.nlm.nih.gov/pubmed/32816380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202008585
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