Fluorescence Anisotropy-Based Tethering for Discovery of Protein–Protein Interaction Stabilizers

[Image: see text] Protein–protein interaction (PPI) networks are fundamental for cellular processes. Small-molecule PPI enhancers have been shown to be powerful tools to fundamentally study PPIs and as starting points for potential new therapeutics. Yet, systematic approaches for their discovery are...

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Udgivet i:ACS Chem Biol
Main Authors: Sijbesma, Eline, Somsen, Bente A., Miley, Galen P., Leijten-van de Gevel, Iris A., Brunsveld, Luc, Arkin, Michelle R., Ottmann, Christian
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7754187/
https://ncbi.nlm.nih.gov/pubmed/33196173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.0c00646
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