Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes

[Image: see text] Current molecular hypotheses have not yet delivered marketable treatments for Alzheimer’s disease (AD), arguably due to a lack of understanding of AD biology and an overreliance on conventional drug modalities. Protein–protein interactions (PPIs) are emerging drug targets, which sh...

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發表在:ACS Chem Neurosci
Main Authors: Andrei, Sebastian A., Meijer, Femke A., Neves, João Filipe, Brunsveld, Luc, Landrieu, Isabelle, Ottmann, Christian, Milroy, Lech-Gustav
格式: Artigo
語言:Inglês
出版: American Chemical Society 2018
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6256345/
https://ncbi.nlm.nih.gov/pubmed/29722962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00118
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