Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products

[Image: see text] Natural compounds are an important class of potent drug molecules including some retrospectively found to act as stabilizers of protein–protein interactions (PPIs). However, the design of synthetic PPI stabilizers remains an understudied approach. To date, there are limited example...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Wolter, Madita, de Vink, Pim, Neves, João Filipe, Srdanović, Sonja, Higuchi, Yusuke, Kato, Nobuo, Wilson, Andrew, Landrieu, Isabelle, Brunsveld, Luc, Ottmann, Christian
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2020
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022324/
https://ncbi.nlm.nih.gov/pubmed/32501683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c02151
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