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Cooperativity basis for small-molecule stabilization of protein–protein interactions
A cooperativity framework to describe and interpret small-molecule stabilization of protein–protein interactions (PPI) is presented. The stabilization of PPIs is a versatile and emerging therapeutic strategy to target specific combinations of protein partners within the protein interactome. Currentl...
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| Pubblicato in: | Chem Sci |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Royal Society of Chemistry
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6429609/ https://ncbi.nlm.nih.gov/pubmed/30996864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8sc05242e |
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