Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products

[Image: see text] Natural compounds are an important class of potent drug molecules including some retrospectively found to act as stabilizers of protein–protein interactions (PPIs). However, the design of synthetic PPI stabilizers remains an understudied approach. To date, there are limited example...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Am Chem Soc
Päätekijät: Wolter, Madita, de Vink, Pim, Neves, João Filipe, Srdanović, Sonja, Higuchi, Yusuke, Kato, Nobuo, Wilson, Andrew, Landrieu, Isabelle, Brunsveld, Luc, Ottmann, Christian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2020
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8022324/
https://ncbi.nlm.nih.gov/pubmed/32501683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.0c02151
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia